A third case of the mysterious childhood hepatitis in Belgium

About 230 children worldwide have recently suffered from acute hepatitis of yet unknown origin. Belgium has 3 cases. Several avenues are being explored.

A third case of acute hepatitis affecting children was reported Wednesday in Belgium by Sciensano. In the world, nearly 230 young people suffer from acute inflammation of the liver not explained have already been listed.

This is last April 5th that the United Kingdom had reported to increase the number of children suffering from symptoms of unknown origin. Since that date, the number of detected cases has increased.


This disease causes severe inflammation of the liver in children, normally little affected by this problem. Symptoms consist of abdominal pain, diarrhea, even jaundice (jaundice). Most patients do not have a fever.

In Belgium, Sciensano expects an increase in case reports.

The victims

This hepatitis affects children aged one month to 16 years, depending on the cases reported. Most patients are under the age of 10 e many are less than 5 years old.

They were in good health, with no comorbidities before they were affected. Most of them didn’t has not been vaccinated against covid.

Number of cases


Since the beginning of April, 190 children with the mysterious hepatitis have been registered worldwide. There is a case in Belgium.

WHO estimates there are about 230 cases worldwide, including more than 55 confirmed cases in European Union countries and Norway. At least 111 cases have been detected in the UK.

The United States and Israel also listed the patients.

In Belgium, three children were diagnosed with this mysterious form of liver inflammation between February and April. According to Sciensano, they are all aged children between 1 month and 10 years. One of the three children, whose infection is the most recent, is currently stopped hospitalized. A second has never been hospitalized, the third child has already been discharged from the hospital.


“Currently, the exact cause of hepatitis remains unknown,” admits the European Center for Disease Prevention and Control (ECDC). No link with contaminated food, drink or toys has yet been identified. An infectious cause therefore appears to be considered the most likely.

The usual viruses that cause acute viral hepatitis (A to E) were not detected in any of the new cases.

Scientists are currently in favor of a adenovirus infection. Adenoviruses generally cause respiratory symptoms (bronchitis, pharyngitis, etc., and in some cases pneumonia), eye symptoms (conjunctivitis), and digestive disorders (gastroenteritis). Transmission occurs via the fecal-oral or respiratory route, often in communities (nursery schools, schools). Most patients get infected before age 5.

It could be a new strain of adenovirus.

But their role in the development of this hepatitis is unclear. Adenoviruses were found in 74 sick children. 18 were carriers of adenovirus type 41. But the latter is not described as responsible for hepatitis in healthy children. And overall, young adenovirus infected patients who develop hepatitis are usually immunocompromised children; this is not the case with current patients.

Two avenues are being explored. It could be a new adenovirus strain. Or other infections, or even environmental causes, could increase inflammation of adenoviral origin.

Ties to Covid

The possibility of a relationship with Covid-19 is one of the hypotheses, but the link would be indirect. Pandemic and imprisonment would have weakened the children’s immune systemswhich became more sensitive due to a lower level of adenovirus circulation during the covid period.

Co-infection with SARS-CoV-2 is also considered, but covid was not detected in all patients.

Prevention, treatment and drugs

Common preventive measures against adenovirus and other common infections involve regular hand washing and respiratory hygiene, recalls the WHO.

Of the children treated for this acute hepatitis, at least 17 had to receive a kidney transplant. A child died.

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